PGT-A

PGT-A is available to any patient, but is typically prescribed for^1,2:

• Couples where the female patient is of advanced maternal age (35 years or older)
• Patients who have experienced recurrent pregnancy losses both naturally and/or through IVF
• Patients who have experienced recurrent implantation failure
• Couples where severe male factor infertility has been identified

The published benefits of PGT-A include^1-5:

• Increased pregnancy rates per transfer
• Reduced time between IVF cycles and, therefore, overall time to pregnancy
• Reduced miscarriage rates^3,4
• Increased confidence in single embryo transfers, avoiding the associated risks with multiple birth pregnancies

For every embryo tested, the different possible results are:

1. ESHRE PGT Consortium Steering Committee, Carvalho F, Coonen E, et al. ESHRE PGT Consortium good practice recommendations for the organisation of PGT. Hum Reprod Open. 2020;2020(3):hoaa021. Published 2020 May 29. doi:10.1093/hropen/hoaa021.
2. Practice Committees of the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology. The use of preimplantation genetic testing for aneuploidy (PGT-A): a committee opinion. Fertil Steril. 2018;109(3):429-436. doi:10.1016/j.fertnstert.2018.01.002.
3. Rubio C, Bellver J, Rodrigo L, et al. In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril. 2017;107(5):1122-1129. doi:10.1016/j.fertnstert.2017.03.011.
4. Anderson RE, Whitney JB, Schiewe MC. Clinical benefits of preimplantation genetic testing for aneuploidy (PGT-A) for all in vitro fertilization treatment cycles. Eur J Med Genet. 2020;63(2):103731. doi:10.1016/j.ejmg.2019.103731.
5. Gorodeckaja J, Neumann S, McCollin A, et al. High implantation and clinical pregnancy rates with single vitrified-warmed blastocyst transfer and optional aneuploidy testing for all patients [published online ahead of print, 2019 Jan 7]. Hum Fertil (Camb). 2019;1-12. doi:10.1080/14647273.2018.1551628.
6. Tiegs AW, Tao X, Zhan Y, et al. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy [published online ahead of print, 2020 Aug 27]. Fertil Steril. 2020;S0015-0282(20)30711-1. doi:10.1016/j.fertnstert.2020.07.052.
7. Munné S, Kaplan B, Frattarelli JL, et al. Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial. Fertil Steril. 2019;112(6):1071-1079.e7. doi:10.1016/j.fertnstert.2019.07.1346.